Methyl Glyoxal
Indian Scientist Dr. Manu Ray and team from IACS Kolkatta has developed a non-toxic method of chemotherapy. Methyl Glyoxal (MG) is a simple organic chemical found in small quantities in body. IT was seen that in cancer patients, levels of MG become very low.A recent, Clinical trail shows that MG disrupts the excessive
biosynthesis of ATP responsible for the overgrowth (Mitochondrial Adenosine-tri-phosphate) in cancer cells only thus leading to selective destruction of cancer cells. Dr. Ray, has developed a method to administer MG with some other micronutrients orally and by injections. This method was tested on animal models and cancer patients in Clinical trials with the permission from Drug Controller General of India. In continuing to it an upgraded version has been introduced by Dr. Manju Ray ‘Development and optimization of nano-particle based MG’ Methylglyoxal anchored in nanoparticles was detected by Fourier transform infrared spectroscopy (FTIR) & was also estimated using uv-visible spectrophotometer. Tumor growth inhibition of Ehrlich ascites carcinoma (EAC) cells in mice with nano-methylglyoxal were studied both invitro & in vivo. This drug is found to be non-toxic. All these suggest the polymer conjugated nano methylglyoxal is a very good drug candidate for the cancer therapy and for that further work is in progress.